19-22 October 2011
Hotel Roanoke, Roanoke VA
US/Eastern timezone
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Physical properties of unacetylated chromatin as examined by magnetic tweezers

21 Oct 2011, 18:00
2h
Roanoke Foyer (Hotel Roanoke, Roanoke VA)

Roanoke Foyer

Hotel Roanoke, Roanoke VA

Poster (undergraduate) LA. Poster Session

Speaker

Kerry McGill (North Georgia College and State University)

Description

As the source of genetic material, DNA is involved in a variety of biological processes like transcription, cell replication, and more. In these processes, DNA is manipulated into different structures and is subjected to different levels of physical force on a molecular scale. When tension is applied to one hierarchical structure called chromatin, it appears to behave like a Hookian spring. The base component of chromatin is a nucleosome, which is constructed when DNA coils around octamers of histone proteins. The histones can become acetylated---a chemical process in which an acetyl functional group attaches to amino acids of the histones, often lysines. Acetylation may loosen chromatin's coils and therefore lower the amount of tension required to stretch the chromatin. Comparing the levels of tension required to stretch acetylated chromatin could reveal, directly, physical differences in the chromatin fiber that bear ion the function of the DNA molecule. Work presented will be the investigation of unacetylated chromatin.

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