19-22 October 2011
Hotel Roanoke, Roanoke VA
US/Eastern timezone
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Utilizing protein networks to determine novel annotations

20 Oct 2011, 11:21
Crystal Ballroom C (Hotel Roanoke, Roanoke VA)

Crystal Ballroom C

Hotel Roanoke, Roanoke VA


Kenneth Shiao


Proteins are a key element of life because they are involved in every metabolic process, yet a majority of proteins remain unannotated. Current chemical and physical annotation methods are inaccurate, inefficient, or expensive. Without proper annotation, understanding of organisms' metabolic pathways is limited. Based on the hypothesis that proteins with similar primary structures have similar characteristics, we theorize that a method for protein annotation can be developed using protein networking, which was previously thought to be useful in determining the evolutionary paths of proteins. A large, diverse database of proteins is used to connect protein fragments by using a preset identity threshold. With this method, unknown proteins are connected to known ones. By observing the number of links to proteins with annotated functions, a likely annotation candidate will be reached. This procedure can potentially facilitate the process of finding more accurate annotations. We have used and validated this approach to annotate putative uncharacterized proteins. Results will be presented at the conference.


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